Endocrine Abstracts

Background: Cerebral malaria may present with altered cognition, severe hemolysis, renal and metabolic dysfunction. The endocrine abnormalities induced by malaria include: hypoglycemia, hypocalcemia, hypercortisolism and compromised pituitary function due to sequestration of drepanocytes in hypothalamo-pituitary portal microvasculature.Aim: To raise awareness for the risk of pituitary dysfunction in severe malaria.Case: A previousl...

Introduction: Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) represents <2% of all causes of Cushing’s Syndrome (CS). Clinical course is insidious, with adrenal bilateral macronodules and gradual cortisol excess, only rarely presenting with overt CS. The pathophysiology remains unclear in most cases; however, pathogenic variants in the onco-supressor ARMC5 gene are described in 25-50% of PBMAH and may confer a more severe clinical course. <p class="abs...

Introduction: Primary thyroid lymphomas (PTL) account for 5% of all thyroid malignancies. Treatment and prognosis depend on tumor subtype. Contrasting with diffuse large B-cell lymphomas (DLBCL), that have an aggressive clinical course and higher maximum standardized uptake value (SUVmax) in Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET), thyroid extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) usually show an indolen...

Background: Acromegaly is a rare disorder associated with excessive levels of growth hormone(GH) and insulin-like growth factor-1(IGF-1). GH/IGF-1 excess leads to morphologic craniofacial and acral changes as well as cardiometabolic complications, but the phenotypic changes and presentation differ across species.Aim: To present the resemblances and distinctive features of acromegaly in humans, cats and dogs.Methods: A literature re...